The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish.

@article{Mawdsley2004TheNR,
  title={The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish.},
  author={David J Mawdsley and Helen M. Cooper and Benjamin M Hogan and Stephen H. Cody and Graham J. Lieschke and Joan K. Heath},
  journal={Developmental biology},
  year={2004},
  volume={269 1},
  pages={302-15}
}
The Netrin receptor Deleted in colon cancer (Dcc) has been shown to play a pivotal role in the guidance of nascent axons towards the ventral midline in the developing nervous systems of both vertebrates and invertebrates. In contrast, the function during embryogenesis of a second Dcc-like Netrin receptor Neogenin has not yet been defined. We used antisense morpholino oligonucleotides to knockdown Neogenin activity in zebrafish embryos and demonstrate that Neogenin plays an important role in… CONTINUE READING

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