The Neisseria meningitidis haemoglobin receptor: its role in iron utilization and virulence.

@article{Stojiljkovi1995TheNM,
  title={The Neisseria meningitidis haemoglobin receptor: its role in iron utilization and virulence.},
  author={Igor Stojiljkovi{\'c} and Vivian Hwa and Luc de Saint Martin and Peadar O'Gaora and Xavier Nassif and Fred Heffron and Magdalene So},
  journal={Molecular microbiology},
  year={1995},
  volume={15 3},
  pages={531-41}
}
The Neisseria meningitidis haemoglobin receptor gene, hmbR, was cloned by complementation in a porphyrin-requiring Escherichia coli mutant. hmbR encodes an 89.5 kDa outer membrane protein which shares amino acid homology with the TonB-dependent receptors of Gram-negative bacteria. HmbR had the highest similarity to Neisseria transferrin and lactoferrin receptors. The utilization of haemoglobin as an iron source required internalization of the haemin moiety by the cell. The mechanism of haemin… CONTINUE READING