The Neglected Intrinsic Resistome of Bacterial Pathogens

  title={The Neglected Intrinsic Resistome of Bacterial Pathogens},
  author={Alicia Fajardo and Nadia Martinez-Martin and Mar{\'i}a Guadalupe Mercadillo and Juan Carlos Gal{\'a}n and Bart Ghysels and S. J. B. A. Hoppenbrouwers Radboud University Nijmege Matthijs and Pierre Cornelis and Lutz Wiehlmann and Burkhard T{\"u}mmler and Fernando Baquero and Jos{\'e} L Mart{\'i}nez},
  journal={PLoS ONE},
  pages={1376 - 1378}
Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories. Mutations in some genes make P. aeruginosa more… CONTINUE READING
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Handbook of Microbiological Media; Parks LC, editor

  • RM Atlas
  • 1993
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