The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

@article{Oberst2007TheNP,
  title={The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch},
  author={Andrew Oberst and Martina Malatesta and Rami I. Aqeilan and Mario Rossi and Paolo Salomoni and Rodolfo Murillas and Prashant Sharma and Michael R. Kuehn and Moshe Oren and Carlo Maria Croce and Francesca Bernassola and Gerry Melino},
  journal={Proceedings of the National Academy of Sciences},
  year={2007},
  volume={104},
  pages={11280 - 11285}
}
Nedd4-binding partner-1 (N4BP1) has been identified as a protein interactor and a substrate of the homologous to E6AP C terminus (HECT) domain-containing E3 ubiquitin–protein ligase (E3), Nedd4. Here, we describe a previously unrecognized functional interaction between N4BP1 and Itch, a Nedd4 structurally related E3, which contains four WW domains, conferring substrate-binding activity. We show that N4BP1 association with the second WW domain (WW2) of Itch interferes with E3 binding to its… 

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