The Nature of Programmed Cell Death

@article{Durand2018TheNO,
  title={The Nature of Programmed Cell Death},
  author={Pierre M. Durand and Grant Ramsey},
  journal={Biological Theory},
  year={2018},
  volume={14},
  pages={30-41}
}
In multicellular organisms, cells are frequently programmed to die. This makes good sense: cells that fail to, or are no longer playing important roles are eliminated. From the cell’s perspective, this also makes sense, since somatic cells in multicellular organisms require the cooperation of clonal relatives. In unicellular organisms, however, programmed cell death (PCD) poses a difficult and unresolved evolutionary problem. The empirical evidence for PCD in diverse microbial taxa has spurred… 

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References

SHOWING 1-10 OF 155 REFERENCES
Programmed Cell Death and Complexity in Microbial Systems
TLDR
It is concluded that PCD can increase biological complexity in microbial communities and is a means for solving a central problem of group living - the toxic effects of death - by making resources in dying cells beneficial to others.
How an Organism Dies Affects the Fitness of Its Neighbors
TLDR
To test whether PCD could be beneficial to nearby cells, induced programmed and nonprogrammed death in the unicellular green alga Chlamydomonas reinhardtii was induced and revealed that the beneficial effect of the PCD supernatant most likely involves simple heat-stable biomolecules.
“Programmed Cell Death: A Process of Death for Survival” – How Far Terminology Pertinent for Cell Death in Unicellular Organisms
TLDR
This correspondence argues and requests recommendation committee on cell death to revisit for the nomenclature of the cell death process in the unicellular organisms.
On the origin, evolution, and nature of programmed cell death: a timeline of four billion years
  • J. Ameisen
  • Biology, Medicine
    Cell Death and Differentiation
  • 2002
TLDR
It is argued that this new level of complexity, implying that there may be no such thing as a ‘bona fide’ genetic death program in the authors' cells, might be better understood when considered in an evolutionary context.
What is the role and nature of programmed cell death in phytoplankton ecology?
TLDR
The development of this paradigm suggests that there are two morphological outcomes of cell death, one caused by an ‘active’ pathway within the cell (so-called ‘programmed cell death’; PCD), and the other from a ‘passive’ externally-driven process (necrosis).
Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites
TLDR
Bioinformatics analyses suggest that apoptosis mechanisms in protozoan parasites and other taxa have diverged during their evolution, that some apoptosis factors are shared across taxa whilst others have been replaced by proteins with similar biochemical activities.
Are Internal, Death-Promoting Mechanisms Ever Adaptive?
TLDR
The overall picture of POD as a natural phenomenon is still emerging, and continued work on diverse lines of evidence is necessary to complete the evolutionary understanding of this apparent paradox.
Apoptosis-like cell death in unicellular photosynthetic organisms — A review
TLDR
A historical perspective of the occurrence of algal PCD is provided and the key molecular players involved in this process are listed while comparing them with metazoans and multicellular plants.
The Meaning of Death: Evolution and Ecology of Apoptosis in Protozoan Parasites
TLDR
The evolutionary concepts that can explain apoptosis in unicellular parasites are explained, the key questions are highlighted, and the approaches required to resolve the controversy over whether parasites “commit suicide” are outlined.
ON THE PARADIGM OF ALTRUISTIC SUICIDE IN THE UNICELLULAR WORLD
TLDR
It is argued that importing the paradigm of altruistic cell death from multicellular organisms to explain active death in unicellular lineages has the potential to limit the types of questions asked, thus biasing the understanding of the nature, origin, and maintenance of this trait.
...
1
2
3
4
5
...