The Nature of Increased Circulating CD4+CD25-Foxp3+ T Cells in Patients with Systemic Lupus Erythematosus: A Novel Hypothesis

@inproceedings{Yan2009TheNO,
  title={The Nature of Increased Circulating CD4+CD25-Foxp3+ T Cells in Patients with Systemic Lupus Erythematosus: A Novel Hypothesis},
  author={Bing Yan and Yi Liu},
  booktitle={The open rheumatology journal},
  year={2009}
}
The forkhead family transcriptional factor (Foxp3) is an important lineage marker for regulatory T (Treg) cells. Foxp3 expression is primarily restricted to CD4+CD25+ cell population. Recently, an intriguing phenomenon is highlighted that there is a considerable amount of CD4(+)CD25(-)Foxp3(+) T cells present in the peripheral blood of patients with systemic lupus erythematosus (SLE). Up to now, it is still an open question as to the nature of this cell subset. Following an analyses of the… CONTINUE READING

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