The Naturally Occurring Cytochrome P 450 ( P 450 ) 2 B 6 K 262 R Mutant of P 450 2 B 6 Exhibits Alterations in Substrate Metabolism and Inactivation

@inproceedings{Bumpus2005TheNO,
  title={The Naturally Occurring Cytochrome P 450 ( P 450 ) 2 B 6 K 262 R Mutant of P 450 2 B 6 Exhibits Alterations in Substrate Metabolism and Inactivation},
  author={Namandj{\'e} N Bumpus and Chitra Sridar and Ute M. Kent and Paul F. Hollenberg},
  year={2005}
}
The polymorphic human cytochrome P450 (P450) 2B6 is primarily responsible for the metabolism of several clinically relevant drugs including bupropion, cyclophosphamide, propofol, and efavirenz. Although a number of single nucleotide polymorphisms have been found in the P450 2B6 gene, the influence of these variants on the metabolism of substrates and on the response to known inactivators of P450 2B6 has not been examined. We have compared the metabolism of different substrates of P450 2B6 (P450… CONTINUE READING

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