The Naturalistic Course of Unipolar Major Depression in the Absence of Somatic Therapy

  title={The Naturalistic Course of Unipolar Major Depression in the Absence of Somatic Therapy},
  author={Michael A. Posternak and David A. Solomon and Andrew C. Leon and Timothy I. Mueller and M Tracie Shea and Jean Endicott and Martin Keller},
  journal={The Journal of Nervous and Mental Disease},
The goal of the study was to describe the naturalistic course of unipolar major depression in subjects not receiving somatic therapy for their depressive illness. Affectively ill individuals were recruited into the Collaborative Depression Study and followed prospectively for up to 15 years. One hundred thirty subjects who recovered from their intake episode of major depression subsequently experienced a recurrence that went untreated for at least 4 weeks following onset of the recurrence. The… 
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