The Natural History of Vulvar Intraepithelial Neoplasia, Differentiated Type: Evidence for Progression and Diagnostic Challenges

@article{Bigby2016TheNH,
  title={The Natural History of Vulvar Intraepithelial Neoplasia, Differentiated Type: Evidence for Progression and Diagnostic Challenges},
  author={Susan M Bigby and Lois J. Eva and Kah Leng Fong and Ronald W. Jones},
  journal={International Journal of Gynecological Pathology},
  year={2016},
  volume={35},
  pages={574–584}
}
  • S. Bigby, L. Eva, +1 author R. Jones
  • Published 1 November 2016
  • Medicine
  • International Journal of Gynecological Pathology
Squamous cell carcinoma of the vulva (SCCV) develops through either human papillomavirus (HPV)-dependent or HPV-independent pathways. Approximately 60% of SCCV arise independently of HPV, commonly in a background of an inflammatory dermatosis, particularly lichen sclerosus. The likely direct precursor to most of these lesions is vulvar intraepithelial neoplasia (VIN), differentiated type (dVIN), although the evidence is largely circumstantial. There are few reports of progression to carcinoma… Expand
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TLDR
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TLDR
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TLDR
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Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma
TLDR
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Clinicopathologic Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation
TLDR
The morphology of dVIN encompasses nonkeratinizing and keratinizing types, the latter subdivided into traditional, acantholytic, atrophic, hypertrophic, and subtle. Expand
Vulvar Squamous Neoplasia
TLDR
Vulvar cancer affects 2.5 per 100,000 women per year and represents 0.4% of all new cancer cases in the USA, with those between the ages of 75 and 84 most commonly affected. Expand
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