The Natural History of Vestibular Schwannoma

@article{Stangerup2006TheNH,
  title={The Natural History of Vestibular Schwannoma},
  author={Sven Eric Stangerup and Per Cay{\'e}-Thomasen and Mirko Tos and Jens Christian Thomsen},
  journal={Otology \& Neurotology},
  year={2006},
  volume={27},
  pages={547-552}
}
Objective: The incidence of vestibular schwannomas (VSs) approaches 20 per million/yr. As treatment may depend on tumor growth, there is a demand of a treatment strategy based on hard data on the growth pattern of these tumors. This article reports growth data registered prospectively in 552 patients. Study Design: Of the 1,818 consecutive patients, diagnosed with VS during the period from 1975 to 2005, 729 patients were allocated to observation by repetitive magnetic resonance imaging. At… 
The Natural History of Small Vestibular Schwannomas
TLDR
Overall, the findings in this study suggest that vestibular schwannomas measuring ≤ 4 mm are unlikely to grow and ever require treatment.
Conservative management of 386 cases of unilateral vestibular schwannoma: tumor growth and consequences for treatment.
TLDR
The results of this study support the role of a conservative "wait-and-scan" policy of management for small-sized vestibular schwannomas because most have a slow growth rate.
Delayed Tumor Growth in Vestibular Schwannoma: An Argument for Lifelong Surveillance.
  • Robert J. Macielak, Neil S. Patel, M. Carlson
  • Medicine
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2019
TLDR
The findings support the need for lifelong surveillance of untreated VSs given the possibility of clinically significant delayed growth and increasing the time interval between MRI studies after 5 years is a reasonable concession to balance cost and convenience with risk of delayed of tumor growth.
Growth dynamics of the vestibular schwannoma
TLDR
This thesis empirically evaluates different means of reporting tumor size and growth that can be found in the literature concerning vestibular schwannoma, and presents its own findings of the growth dynamics and predictors of untreated VS, as well as evaluating the treatment outcome and complication rates for tumors treated by gamma knife radiosurgery (GKRS).
Growth of untreated vestibular schwannoma: a prospective study.
TLDR
Based on the actual measurements, VDT was the most correct way to describe VS growth, and none of the investigated baseline predictors were usable as predictors of growth.
Volumetric growth rates of untreated vestibular schwannomas.
TLDR
This study comprehensively assessed VS volumetric growth rates using high-resolution images and was conducted in a large and diverse patient sample, finding that larger tumors were associated with increased absolute growth, but there was no relationship between tumor size and proportional growth rate.
Paradoxical trends in the management of vestibular schwannoma in the United States.
TLDR
Study data demonstrated a shift in the management of small VSs in the US between 2004 and 2007, with microsurgical removal giving way to radiation treatment and the overall rate for observation remaining low and stable.
Management of growing vestibular schwannomas
TLDR
Most of the tumours affected by unilateral vestibular schwannomas do not grow; in case of tumour growth, a surgical procedure may be suggested and the outcomes are not negatively influenced by the delay of the procedure.
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