The Natural History of Complex Regional Pain Syndrome

  title={The Natural History of Complex Regional Pain Syndrome},
  author={Robert Jay Schwartzman and Kirsten L Erwin and Guillermo M. Alexander},
  journal={The Clinical Journal of Pain},
ObjectiveComplex regional pain syndrome (CRPS) is a severe chronic pain condition characterized by sensory, autonomic, motor, and dystrophic signs and symptoms. This study was undertaken to expand our current knowledge of the evolution of CRPS signs and symptoms with duration of disease. MethodThis was a retrospective, cross-sectional analysis using data extracted from a patient questionnaire to evaluate the clinical characteristics of CRPS at different time points of disease progression. Data… 

Signs and Symptoms in 1,043 Patients with Complex Regional Pain Syndrome.

  • S. OttC. Maihöfner
  • Medicine, Psychology
    The journal of pain : official journal of the American Pain Society
  • 2018

The outcome of complex regional pain syndrome type 1: a systematic review.

Clinical Course and Impact of Complex Regional Pain Syndrome Confined to the Knee.

The clinical course in terms of the symptoms and signs, health-related quality of life (HR-QoL), and work status of patients diagnosed with complex regional pain syndrome (CRPS) of the knee is investigated.

Time since inciting event is associated with higher centralized pain symptoms in patients diagnosed with complex regional pain syndrome

It is suggested that the longer the patients have CRPS the more likely they are to report symptoms suggestive of centralized pain, which may explain why some patients with a longer duration of CRPS do not respond to peripherally directed therapies.

Determinants of Diagnostic Delay in Complex Regional Pain Syndrome Type 1

Foot localization, CRPS-1 without overt clinical manifestation, previous physiotherapy treatments prescribed before CRPS1 diagnosis, general practitioner's management, and a triggering event other than fracture were associated with a delayed diagnosis.

Complex Regional Pain Syndrome: An Introduction

Complex regional pain syndrome is a chronic pain condition that usually follows minor extremity trauma and is characterized by sensory, vasomotor, sudomotor, and motor/trophic changes and suggests a transition from peripheral to central mechanisms over time.

Postoperative Complex Regional Pain Syndrome

There is some evidence that CRPS may play a primary role in thoracic outlet syndrome patients, but because surgery is so often provided as a treatment for TOS there is an increased overall risk of development of CRPS in this patient group to start with.

Complex regional pain syndrome

  • S. Bruehl
  • Medicine, Psychology
    BMJ : British Medical Journal
  • 2015
Reviews of available randomized trials suggest that physical and occupational therapy, bisphosphonates, calcitonin, subanesthetic intravenous ketamine, free radical scavengers, oral corticosteroids, and spinal cord stimulation may be effective treatments.



Neurological findings in complex regional pain syndromes--analysis of 145 cases.

The detailed knowledge of clinical features of CRPS could help physicians early to recognize the disease and thus to improve therapy outcome.

Vascular abnormalities in reflex sympathetic dystrophy (CRPS I): mechanisms and diagnostic value.

It is suggested that, in CRPS I, unilateral inhibition of sympathetic vasoconstrictor neurones leads to a warmer affected limb in the acute stage, whereas sympathetic activity is still depressed.