The Natural History of Biocatalytic Mechanisms


Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has recently showed that the α/β architecture is probably the oldest fold design. This holds important implications for the origins of biochemistry. Here we explore structure-function relationships addressing the use of chemical mechanisms by ancestral enzymes. We test the… (More)
DOI: 10.1371/journal.pcbi.1003642

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