The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects.

@article{Sun2017TheND,
  title={The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects.},
  author={Xiaoyan Sun and Weiguang Wang and Jiao Chen and Xueting Cai and Jie Yang and Yang Yang and Huaijiang Yan and Xiaolan Cheng and Juan Ye and Wuguang Lu and Chunping Hu and Han-Dong Sun and Jian-Xin Pu and Peng Cao},
  journal={Cancer research},
  year={2017},
  volume={77 4},
  pages={926-936}
}
Aberrant expression of thioredoxin 1 (Trx1) plays an important role in cancer initiation and progression and has gained attention as an anticancer drug target. Here we report that the recently discovered natural diterpenoid isoforretin A (IsoA) significantly inhibits Trx1 activity and mediates anticancer effects in multiple preclinical settings. The inhibitory effect of IsoA was antagonized by free radical scavengers polyethylene glycol-catalase, polyethylene glycol superoxide dismutase, thiol… CONTINUE READING
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