The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons

@inproceedings{Chung2010TheNC,
  title={The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons},
  author={Roger S. Chung and Claire Howells and Emma D. Eaton and Lana Shabala and Kairit Zovo and Peep Palumaa and Rannar Sillard and Adele Woodhouse and William R. Bennett and Shannon N Ray and James Clement Vickers and Adrian West},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND A major pathological hallmark of AD is the deposition of insoluble extracellular beta-amyloid (Abeta) plaques. There are compelling data suggesting that Abeta aggregation is catalysed by reaction with the metals zinc and copper. METHODOLOGY/PRINCIPAL FINDINGS We now report that the major human-expressed metallothionein (MT) subtype, MT-2A, is capable of preventing the in vitro copper-mediated aggregation of Abeta1-40 and Abeta1-42. This action of MT-2A appears to involve a metal… CONTINUE READING
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