The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens.

@article{Eastin1998TheNT,
  title={The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens.},
  author={William C. Eastin and Joseph K. Haseman and Joel F. Mahler and John R. Bucher},
  journal={Toxicologic pathology},
  year={1998},
  volume={26 4},
  pages={461-73}
}
National Institute of Environmental Health Sciences researchers are exploring the utility of genetically altered mice to study mechanisms of carcinogenesis. Two of these mouse models, the Tg.AC (carrier of an activated mouse H-ras oncogene) and the p53+/- (heterozygous for the wild-type tumor suppressor gene Trp53), have genetic alterations that appear to hasten their expression of chemically induced tumors. These 2 models have been proposed as a basis for new strategies for identifying… CONTINUE READING

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