The Narrow Therapeutic Index of Thrombin Inhibition: Implications for Newer Antithrombotic Therapies

@article{Loscalzo1997TheNT,
  title={The Narrow Therapeutic Index of Thrombin Inhibition: Implications for Newer Antithrombotic Therapies},
  author={Joseph Loscalzo},
  journal={Journal of Thrombosis and Thrombolysis},
  year={1997},
  volume={4},
  pages={315-316}
}
Recent trials have compared direct thrombin inhibitors with heparin as adjunctive therapy with thrombolysis for acute myocardial infarction or as antithrombotic therapy following coronary angioplasty. The results suggest that these agents are comparable to heparin in terms of efficacy, and can be safely administered; however, like that of heparin, the… CONTINUE READING