The Na-K-Cl cotransporters.

  title={The Na-K-Cl cotransporters.},
  author={Mark Haas and Biff Forbush},
  journal={Journal of bioenergetics and biomembranes},
  volume={30 2},
The Na-K-Cl cotransporters are a class of membrane proteins that transport Na, K, and Cl ions into and out of a wide variety of epithelial and nonepithelial cells. The transport process mediated by Na-K-Cl cotransporters is characterized by electroneutrality (almost always with stoichiometry of 1Na:1K:2Cl) and inhibition by the "loop" diuretics bumetanide, benzmetanide, and furosemide. Presently, two distinct Na-K-Cl cotransporter isoforms have been identified by cDNA cloning and expression… CONTINUE READING


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