The Na,K-ATPase hypothesis for manic-depression. II. The mechanism of action of lithium.


A model as to how lithium may work in the treatment and prevention of manic-depression is presented. Lithium accumulates intracellularly, and accumulates preferentially in more active neurons. Intracellular accumulation of lithium displaces intracellular sodium, which, in turn, decreases intracellular calcium. A decrease of intracellular calcium normalizes… (More)


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