The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.

@article{Moseley2003TheNA,
  title={The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.},
  author={Amy E. Moseley and Steve P Lieske and Randall K. Wetzel and Peter F. James and Suiwen He and Daniel A. Shelly and R. J. Birch Paul and Gregory P. Boivin and David W. Witte and Jan Marino Ramirez and Kathleen J Sweadner and Jerry B. Lingrel},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 7},
  pages={
          5317-24
        }
}
Na,K-ATPase is an ion transporter that impacts neural and glial physiology by direct electrogenic activity and the modulation of ion gradients. Its three isoforms in brain have cell-type and development-specific expression patterns. Interestingly, our studies demonstrate that in late gestation, the alpha2 isoform is widely expressed in neurons, unlike in the adult brain, in which alpha2 has been shown to be expressed primarily in astrocytes. This unexpected distribution of alpha2 isoform… CONTINUE READING
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