The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate.

@article{Dohn2007TheNS,
  title={The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate.},
  author={Orsolya Doh{\'a}n and Carla Portulano and C{\'e}cile Basquin and Andrea Reyna-Neyra and L. Mario Amzel and Nancy Carrasco},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 51},
  pages={20250-5}
}
The Na(+)/I(-) symporter (NIS) is a key plasma membrane protein that mediates active I(-) uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na(+) per I(-). In the thyroid, NIS-mediated I(-) uptake is the first step in the biosynthesis of the iodine-containing thyroid hormones, which are essential early in life for proper CNS development. In the lactating breast, NIS mediates the translocation of I(-) to the milk, thus supplying this essential… CONTINUE READING

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