The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-α in the primary cilium

@inproceedings{Schneider2009TheNE,
  title={The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-α in the primary cilium},
  author={Linda Schneider and Christian-Martin Stock and Peter Dieterich and Bo Hammer Jensen and Lotte B. Pedersen and Peter Satir and Albrecht Schwab and S\oren Tvorup Christensen and Stine Falsig Pedersen},
  booktitle={The Journal of cell biology},
  year={2009}
}
We previously demonstrated that the primary cilium coordinates platelet-derived growth factor (PDGF) receptor (PDGFR) alpha-mediated migration in growth-arrested fibroblasts. In this study, we investigate the functional relationship between ciliary PDGFR-alpha and the Na(+)/H(+) exchanger NHE1 in directional cell migration. NHE1 messenger RNA and protein levels are up-regulated in NIH3T3 cells and mouse embryonic fibroblasts (MEFs) during growth arrest, which is concomitant with cilium… CONTINUE READING

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The changing face of the Na + / H + exchanger , NHE 1 : structure , regulation , and cellular actions

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