The NZB mouse as a model for chronic lymphocytic leukemia.

  title={The NZB mouse as a model for chronic lymphocytic leukemia.},
  author={John A. Phillips and Kapil Deo Mehta and C{\'e}sar Guti{\'e}rrez Fern{\'a}ndez and Elizabeth S. Raveche},
  journal={Cancer research},
  volume={52 2},
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and the only leukemia for which a possible genetic component has been described. Analysis of this genetic component has been hindered by the fact that disease onset normally occurs after age 50. We report here the aged NZB mouse as an animal model for CLL. NZB mice have a genetically regulated, age-dependent onset of clonal, aneuploid cells which are IgM+ and Ly1+ (CD5+ B-cells). Peripheral blood smears from old… CONTINUE READING


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