The NZB mouse as a model for chronic lymphocytic leukemia.

@article{Phillips1992TheNM,
  title={The NZB mouse as a model for chronic lymphocytic leukemia.},
  author={John A. Phillips and Kapil Deo Mehta and C{\'e}sar Guti{\'e}rrez Fern{\'a}ndez and Elizabeth S. Raveche},
  journal={Cancer research},
  year={1992},
  volume={52 2},
  pages={437-43}
}
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and the only leukemia for which a possible genetic component has been described. Analysis of this genetic component has been hindered by the fact that disease onset normally occurs after age 50. We report here the aged NZB mouse as an animal model for CLL. NZB mice have a genetically regulated, age-dependent onset of clonal, aneuploid cells which are IgM+ and Ly1+ (CD5+ B-cells). Peripheral blood smears from old… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 53 references

Cloning immuno globulin variable domains for expression by the polymerase chain reaction

R. Oriundi, D. H. Gussow, P. T. Jones, G. Winter
Proc. Nati. Acad. Sci. USA, • 1989
View 6 Excerpts
Highly Influenced

In vivo effecls of hyperdiploid Lyl* B cells of NZB origin

E. S. RavechÃ, P. Lalor, A. Siali, J. Conroy
J. Immunol., • 1988
View 7 Excerpts
Highly Influenced

Cytokines in NZB CD5+ B clones.

Annals of the New York Academy of Sciences • 1992
View 1 Excerpt

IL-10: a novel cyloloxic T cell differenlialion faclor

Chen, W-F, A. Zlotnik
J. Immunol., • 1991
View 1 Excerpt

Characterizalion of a B cell helper faclor(s) derived from CD5+ B cell hybridomas

I lanlin, M.J.A.. Gibson, +5 authors D. H. Sherr
Cell. Immunol., • 1990
View 1 Excerpt

Idenlificalion of a novel Ihymocyte growth-promoting factor derived from B cell lymphomas

T. Suda, A. O'Garra, +3 authors A. Zlolnik
Cell. Immunol., • 1990
View 1 Excerpt

Possible immunoregulatory role for CD5 + B cells.

Clinical immunology and immunopathology • 1990
View 1 Excerpt

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