The NYCBH vaccinia virus deleted for the innate immune evasion gene, E3L, protects rabbits against lethal challenge by rabbitpox virus.

@article{Denzler2011TheNV,
  title={The NYCBH vaccinia virus deleted for the innate immune evasion gene, E3L, protects rabbits against lethal challenge by rabbitpox virus.},
  author={Karen L. Denzler and Amanda D. Rice and A. Luke MacNeill and Nobuko Fukushima and Scott F Lindsey and Greg Wallace and Andrew M. Burrage and Andrew P. Smith and Brandi R. Manning and Daniele M Swetnam and Stacey A. Gray and Richard W. Moyer and Bertram L Jacobs},
  journal={Vaccine},
  year={2011},
  volume={29 44},
  pages={7659-69}
}
Vaccinia virus deleted for the innate immune evasion gene, E3L, has been shown to be highly attenuated and yet induces a protective immune response against challenge by homologous virus in a mouse model. In this manuscript the NYCBH vaccinia virus vaccine strain was compared to NYCBH vaccinia virus deleted for E3L (NYCBHΔE3L) in a rabbitpox virus (RPV) challenge model. Upon scarification, both vaccines produced a desired skin lesion, although the lesion produced by NYCBHΔE3L was smaller. Both… CONTINUE READING
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