The NTplus method of screening for Down syndrome: achieving the 2010 targets?

@article{Habayeb2010TheNM,
  title={The NTplus method of screening for Down syndrome: achieving the 2010 targets?},
  author={Osama M H Habayeb and Sandy F Goodburn and Trish Chudleigh and Jeremy C Brockelsby and Hannah H Missfelder-Lobos and Gerald Hackett and Christoph Lees},
  journal={Prenatal diagnosis},
  year={2010},
  volume={30 5},
  pages={434-7}
}
INTRODUCTION The performance of pregnancy-associated plasma protein-A (PAPP-A) as a first trimester trisomy 21 marker is hypothesized to improve below 11 weeks, whereas beta-human chorionic gonadotrophin (hCG) is better after 14 weeks. We audited a model combining early PAPP-A (9-10 weeks) with NT (11-13 weeks and 6 days) and early triple test (>14 weeks). METHODS A total of 1507 women with viable ongoing pregnancies were screened during 2007-2008. First-stage 'screen-positive' risk was based… CONTINUE READING