The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid

@inproceedings{Yufenyuy2012TheNI,
  title={The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid},
  author={Ernest L. Yufenyuy and Christopher Aiken},
  booktitle={Retrovirology},
  year={2012}
}
Lentiviruses exhibit a cone-shaped capsid composed of subunits of the viral CA protein. The intrinsic stability of the capsid is critical for HIV-1 infection, since both stabilizing and destabilizing mutations compromise viral infectivity. Structural studies have identified three intersubunit interfaces in the HIV-1 capsid, two of which have been previously studied by mutational analysis. In this present study we analyzed the role of a third interface, that which is formed between the amino… CONTINUE READING