The NS5a gene of hepatitis C virus in patients treated with interferon-alpha.

@article{McKechnie2000TheNG,
  title={The NS5a gene of hepatitis C virus in patients treated with interferon-alpha.},
  author={V M McKechnie and Peter R. Mills and Elizabeth A B McCruden},
  journal={Journal of medical virology},
  year={2000},
  volume={60 4},
  pages={367-78}
}
Patients infected with hepatitis C virus (HCV) genotype 3 have a better response to interferon-alpha (IFN-alpha) therapy than those infected with genotype 1. There are extensive sequence differences between genotypes in the 3' half of the NS5a gene. An association between IFN-alpha response and the interferon sensitivity-determining region (ISDR) (amino acids 2209-2248) of HCV genotype 1b has been described [Enomoto et al. (1996) New England Journal of Medicine 334:771-776]. A prospective study… CONTINUE READING

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