The NS2 protein of hepatitis C virus is a transmembrane polypeptide.

@article{Santolini1995TheNP,
  title={The NS2 protein of hepatitis C virus is a transmembrane polypeptide.},
  author={E Santolini and Laura Pacini and Cristina Fipaldini and Giovanni Migliaccio and Nicola La Monica},
  journal={Journal of virology},
  year={1995},
  volume={69 12},
  pages={7461-71}
}
The NS2 protein of hepatitis C virus (HCV) is released from its polyprotein precursor by two proteolytic cleavages. The N terminus of this protein is separated from the E2/p7 polypeptide by a cleavage thought to be mediated by signal peptidase, whereas the NS2-3 junction located at the C terminus is processed by a viral protease. To characterize the biogenesis of NS2 encoded by the BK strain of HCV, we have defined the minimal region of the polyprotein required for efficient cleavage at the NS2… CONTINUE READING

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