The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses.

@article{Seo2004TheNG,
  title={The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses.},
  author={Sang Heui Seo and Erich Hoffmann and Robert James Webster},
  journal={Virus research},
  year={2004},
  volume={103 1-2},
  pages={107-13}
}
The H5N1 influenza viruses transmitted to humans in 1997 were highly virulent, but the mechanism of their virulence in humans is largely unknown. Here we show that lethal H5N1 influenza viruses, unlike other human, avian, and swine influenza viruses, are resistant to the anti-viral effects of interferons and tumor necrosis factor alpha The nonstructural (NS) gene of H5N1 viruses is associated with this resistance. Pigs infected with recombinant human H1N1 influenza virus that carried the H5N1… CONTINUE READING
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