The NRTIs Lamivudine, Stavudine and Zidovudine Have Reduced HIV-1 Inhibitory Activity in Astrocytes

  title={The NRTIs Lamivudine, Stavudine and Zidovudine Have Reduced HIV-1 Inhibitory Activity in Astrocytes},
  author={Lachlan R. Gray and Gilda Tachedjian and Anne M. Ellett and Michael J Roche and Wan-Jung Cheng and Gilles J Guillemin and B J Brew and Stuart G. Turville and Steve Lodewijk Wesselingh and Paul R. Gorry and Melissa J. Churchill},
  booktitle={PloS one},
HIV-1 establishes infection in astrocytes and macroage-lineage cells of the central nervous system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the CNS, and are therefore often used in neurologically active combined antiretroviral therapy (Neuro-cART) regimens, but their relative activity in the different susceptible CNS cell populations is unknown. Here, we determined the HIV-1 inhibitory activity of CNS-penetrating ARVs in astrocytes and macrophage-lineage cells. Primary human… CONTINUE READING
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