The NRAMP6 metal transporter contributes to cadmium toxicity.

@article{Cailliatte2009TheNM,
  title={The NRAMP6 metal transporter contributes to cadmium toxicity.},
  author={R{\'e}my Cailliatte and Bruno Lapeyre and J. Briat and St{\'e}phane Mari and Catherine Curie},
  journal={The Biochemical journal},
  year={2009},
  volume={422 2},
  pages={217-28}
}
NRAMP (natural resistance-associated macrophage protein) homologues are evolutionarily conserved bivalent metal transporters. In Arabidopsis, AtNRAMP3 and AtNRAMP4 play a key role in iron nutrition of the germinating plantlet by remobilizing vacuolar iron stores. In the present paper we describe the molecular and physiological characterization of AtNRAMP6. AtNRAMP6 is predominantly expressed in the dry seed embryo and to a lesser extent in aerial parts. Its promoter activity is found diffusely… CONTINUE READING

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We used an AtNRAMP6::HA ( where HA is haemagglutinin ) fusion , shown to be functional in yeast , to demonstrate through immunoblot analysis of membrane fractions and immunofluorescence localization that , in yeast cells , AtNRAMP6 is targeted to a vesicular - shaped endomembrane compartment distinct from the vacuole or mitochondria .
We used an AtNRAMP6::HA ( where HA is haemagglutinin ) fusion , shown to be functional in yeast , to demonstrate through immunoblot analysis of membrane fractions and immunofluorescence localization that , in yeast cells , AtNRAMP6 is targeted to a vesicular - shaped endomembrane compartment distinct from the vacuole or mitochondria .
We used an AtNRAMP6::HA ( where HA is haemagglutinin ) fusion , shown to be functional in yeast , to demonstrate through immunoblot analysis of membrane fractions and immunofluorescence localization that , in yeast cells , AtNRAMP6 is targeted to a vesicular - shaped endomembrane compartment distinct from the vacuole or mitochondria .
We used an AtNRAMP6::HA ( where HA is haemagglutinin ) fusion , shown to be functional in yeast , to demonstrate through immunoblot analysis of membrane fractions and immunofluorescence localization that , in yeast cells , AtNRAMP6 is targeted to a vesicular - shaped endomembrane compartment distinct from the vacuole or mitochondria .
Its promoter activity is found diffusely distributed in cotyledons and hypocotyl , as well as in the vascular tissue region of leaf and flower .
Its promoter activity is found diffusely distributed in cotyledons and hypocotyl , as well as in the vascular tissue region of leaf and flower .
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