The NR2B subunit in NMDA receptors is functionally important during cerebellar granule cell migration.

@article{Mancini2007TheNS,
  title={The NR2B subunit in NMDA receptors is functionally important during cerebellar granule cell migration.},
  author={Jayme D. Mancini and William D. Atchison},
  journal={Neuroscience letters},
  year={2007},
  volume={429 2-3},
  pages={87-90}
}
Migration of cerebellar granule cells (CGCs) from the external germinal cell layer (EGL) to the internal granule cell layer (IGL) within the cerebellar cortex is a crucial developmental process. Antagonists to NMDA receptors impair CGC migration significantly, but studies to determine which subunit subtypes control or affect migration have been controversial. Migrating CGCs transiently express NMDA receptor subunit subtypes NR1a plus NR2B. Grafted NR1-/- subunit knockout cells continue to… CONTINUE READING

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