The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.

@article{Michelakis2003TheN,
  title={The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.},
  author={Evangelos D Michelakis and Michael Sean McMurtry and Brian Sonnenberg and Stephen L Archer},
  journal={Advances in experimental medicine and biology},
  year={2003},
  volume={543},
  pages={293-322}
}
The prognosis of patients with pulmonary arterial hypertension (PAH) is poor. Available therapies (Ca(++)-channel blockers, epoprostenol, bosentan) have limited efficacy or are expensive and associated with significant complications. PAH is characterized by vasoconstriction, thrombosis in-situ and vascular remodeling. Endothelial-derived nitric oxide (NO) activity is decreased, promoting vasoconstriction and thrombosis. Voltage-gated K+ channels (Kv) are downregulated, causing depolarization… CONTINUE READING
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