The NMR-derived conformation of neuropeptide AF, an orphan G-protein coupled receptor peptide.

@article{Miskolzie2003TheNC,
  title={The NMR-derived conformation of neuropeptide AF, an orphan G-protein coupled receptor peptide.},
  author={Mark Miskolzie and George Kotovych},
  journal={Biopolymers},
  year={2003},
  volume={69 2},
  pages={201-15}
}
The tertiary structure of the pain modulating and anti-opiate neuropeptide, human neuropeptide AF (NPAF) (the sequence is AGEGLNSQFWSLAAPQRF-NH(2)), was determined by (1)H-NMR. The structure of NPAF was determined in two solvent systems, namely 50%/50% trifluoroethanol-d(3)/H(2)O (TFE/H(2)O) and in the cell membrane mimetic micelle, sodium dodecylsulfate-d… CONTINUE READING