The NMDAR Subunit NR2B Expression is Modified in Hippocampus after Repetitive Seizures

@article{Auzmendi2008TheNS,
  title={The NMDAR Subunit NR2B Expression is Modified in Hippocampus after Repetitive Seizures},
  author={Jer{\'o}nimo Auzmendi and Natalia Carballo Gonz{\'a}lez and Elena Girardi},
  journal={Neurochemical Research},
  year={2008},
  volume={34},
  pages={819-826}
}
NMDA receptor is involved in synaptic plasticity, learning, memory and neurological diseases like epilepsia and it is the major mediator of excitotoxicity. NR2B-containing NMDA receptors may be playing a crucial role in epileptic disorders. In the present study the effect of the convulsant drug 3-mercaptopropionic acid (MP) repetitive administration (4–7 days) on the hippocampal NR2B subunit was studied. A significant decrease in NR2B in the whole hippocampus was observed after MP4 with a… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

localization, functional properties, regulation and clinical implications

  • JM Loftis, Janowsky A The N-methyl-D-aspartate receptor subunit NR2B
  • Pharmacol Ther 97:55–85. doi:10.1016/ S0163-7258…
  • 2009
1 Excerpt

Differential regulation of N - methyl - D - aspartate receptor subunit messenger RNAs in kindling - induced epileptogenesis

  • E Gashi, J Avallone, T Webster
  • Neuroscience
  • 2007