• Chemistry, Medicine
  • Published in
    Journal of applied toxicology…
    2001
  • DOI:10.1002/jat.805

The NMDA receptor ion channel: a site for binding of Huperzine A.

@article{Gordon2001TheNR,
  title={The NMDA receptor ion channel: a site for binding of Huperzine A.},
  author={Richard K. Gordon and Sandeep Nigam and Julie Weitz and Jitendra R. Dave and Bhupendra P. Doctor and Haresh S. Ved},
  journal={Journal of applied toxicology : JAT},
  year={2001},
  volume={21 Suppl 1},
  pages={
          S47-51
        }
}
Huperzine A (HUP-A), first isolated from the Chinese club moss Huperzia serrata, is a potent, reversible and selective inhibitor of acetylcholinesterase (AChE) over butyrylcholinesterase (BChE) (Life Sci. 54: 991-997). Because HUP-A has been shown to penetrate the blood-brain barrier, is more stable than the carbamates used as pretreatments for organophosphate poisoning (OP) and the HUP-A:AChE complex has a longer half-life than other prophylactic sequestering agents, HUP-A has been proposed as… CONTINUE READING

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