The NMDA receptor antagonist MK-801 elicits conditioned place preference in rats.

@article{Layer1993TheNR,
  title={The NMDA receptor antagonist MK-801 elicits conditioned place preference in rats.},
  author={Richard T. Layer and F G Kaddis and Lane J. Wallace},
  journal={Pharmacology, biochemistry, and behavior},
  year={1993},
  volume={44 1},
  pages={245-7}
}
(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate, (MK-801) a potent noncompetitive antagonist of central NMDA receptors, has been hypothesized to have rewarding properties indicative of abuse potential. To test this hypothesis, the effects of MK-801 on the acquisition of a conditioned place preference and on locomotor activity were assessed and compared with d-amphetamine. Both MK-801 (0.03 and 0.1 mg/kg, SC) and d-amphetamine (1.0 mg/kg, SC) administration resulted in… CONTINUE READING

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