The NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium.

@article{Ghasemi2011TheNR,
  title={The NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium.},
  author={Mehdi Keshavarz Ghasemi and Ahmad Reza Dehpour},
  journal={Trends in pharmacological sciences},
  year={2011},
  volume={32 7},
  pages={
          420-34
        }
}
Although lithium has largely met its initial promise as the first drug discovered in the modern era of psychopharmacology, to date no definitive mechanism for its effects has been established. It has been proposed that lithium exerts its therapeutic effects by interfering with signal transduction through G-protein-coupled receptor (GPCR) pathways or direct inhibition of specific targets in signaling systems, including inositol monophosphatase and glycogen synthase kinase-3 (GSK-3). Recently… CONTINUE READING
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