The NMDA antagonist memantine impairs classical eyeblink conditioning in humans.

@article{Schugens1997TheNA,
  title={The NMDA antagonist memantine impairs classical eyeblink conditioning in humans.},
  author={Markus M. Schugens and R Egerter and Irene Daum and Karsten Schepelmann and Thomas Klockgether and P A L{\"o}schmann},
  journal={Neuroscience letters},
  year={1997},
  volume={224 1},
  pages={57-60}
}
The present study investigated the effects of a single oral dose (30 mg) of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine on memory and learning in human subjects. Sixteen male healthy volunteers participated in a double blind placebo controlled study. There were no significant effects of memantine on mood, attention or immediate and delayed verbal and visuospatial memory. Memantine did, however, delay the acquisition of classical eyeblink conditioning and… CONTINUE READING

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