The NLRP3 rs10754558 polymorphism is a risk factor for preeclampsia in a Chinese Han population.

@article{Xu2018TheNR,
  title={The NLRP3 rs10754558 polymorphism is a risk factor for preeclampsia in a Chinese Han population.},
  author={Longqiang Xu and Sai Li and Zhen Liu and Shuting Jiang and Jingli Wang and Mingzhen Guo and Xin Zhao and Weiqing Song and Shiguo Liu},
  journal={The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
  year={2018},
  pages={1-8}
}
OBJECTIVE Previous studies have indicated that the nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3) inflammasome is activated by monosodium urate in the trophoblast of preeclampsia (PE) patients, leading to augmented placental IL-1β levels. Thus, the purpose of our study was to investigate the association between NLRP3 polymorphisms, rs10754558 and rs2027432, and PE in Chinese Han population. METHODS The NLRP3 polymorphisms, rs10754558 and rs2027432, were genotyped… CONTINUE READING