The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

@article{Allen2009TheNI,
  title={The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.},
  author={Irving C Allen and Margaret A Scull and Chris B. Moore and Eda K Holl and Erin McElvania-Tekippe and Debra J. Taxman and Elizabeth H. Guthrie and Raymond J. Pickles and Jenny P-Y Ting},
  journal={Immunity},
  year={2009},
  volume={30 4},
  pages={556-65}
}
The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic stimuli. However, in vivo evidence for the involvement of NLR proteins in viral sensing has not been widely investigated and remains controversial. As a test of the physiologic role of the NLR molecule NLRP3 during RNA viral infection, we explored the in vivo role of NLRP3 inflammasome components during influenza virus infection. Mice lacking… CONTINUE READING
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