The NLRP12 inflammasome recognizes Yersinia pestis.

@article{Vladimer2012TheNI,
  title={The NLRP12 inflammasome recognizes Yersinia pestis.},
  author={Gregory I. Vladimer and Dan Weng and Sara W. Montminy Paquette and Sivapriya Kailasan Vanaja and Vijay A. K. Rathinam and Marie Hjelmseth Aune and Joseph E. Conlon and Joseph J. Burbage and Megan K Proulx and Qin Liu and George W. Reed and Joan Mecsas and Yoichiro Iwakura and John Bertin and Jon D Goguen and Katherine A. Fitzgerald and Egil Lien},
  journal={Immunity},
  year={2012},
  volume={37 1},
  pages={
          96-107
        }
}
  • Gregory I. Vladimer, Dan Weng, +14 authors Egil Lien
  • Published in Immunity 2012
  • Medicine, Biology
  • Yersinia pestis, the causative agent of plague, is able to suppress production of inflammatory cytokines IL-18 and IL-1β, which are generated through caspase-1-activating nucleotide-binding domain and leucine-rich repeat (NLR)-containing inflammasomes. Here, we sought to elucidate the role of NLRs and IL-18 during plague. Lack of IL-18 signaling led to increased susceptibility to Y. pestis, producing tetra-acylated lipid A, and an attenuated strain producing a Y. pseudotuberculosis-like hexa… CONTINUE READING

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