The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

  title={The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus},
  author={Yue Zhao and Jieling Yang and Jianjin Shi and Yi-Nan Gong and Qiuhe Lu and Hao Xu and Liping Liu and Feng Shao},
Inflammasomes are large cytoplasmic complexes that sense microbial infections/danger molecules and induce caspase-1 activation-dependent cytokine production and macrophage inflammatory death. The inflammasome assembled by the NOD-like receptor (NLR) protein NLRC4 responds to bacterial flagellin and a conserved type III secretion system (TTSS) rod component. How the NLRC4 inflammasome detects the two bacterial products and the molecular mechanism of NLRC4 inflammasome activation are not… 

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Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

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