The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy.

@article{Pescovitz1986TheNE,
  title={The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy.},
  author={Ora Hirsch Pescovitz and Florence Comite and Karen Hench and Kevin M. Barnes and Andrea T. McNemar and Carol M. Foster and Dan Kenigsberg and Donald L Loriaux and Gordon B. Cutler},
  journal={The Journal of pediatrics},
  year={1986},
  volume={108 1},
  pages={
          47-54
        }
}
Between 1979 and 1983, 129 children (95 girls) with precocious puberty were referred to the National Institutes of Health and received treatment for at least 6 months with the long-acting LHRH analogue D-Trp6-Pro9-NEt-LHRH. The majority (107 of 129) of the children had central precocious puberty mediated by activation of the hypothalamic-pituitary-gonadal axis in association with hypothalamic hamartomas (24 of 107) or other central nervous system lesions (21 of 107), or idiopathic precocious… CONTINUE READING
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