The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling.

@article{Commisso2006TheND,
  title={The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling.},
  author={Cosimo Commisso and Gabrielle L Boulianne},
  journal={Molecular biology of the cell},
  year={2006},
  volume={18 1},
  pages={
          1-13
        }
}
Notch signaling, which is crucial to metazoan development, requires endocytosis of Notch ligands, such as Delta and Serrate. Neuralized is a plasma membrane-associated ubiquitin ligase that is required for neural development and Delta internalization. Neuralized is comprised of three domains that include a C-terminal RING domain and two neuralized homology repeat (NHR) domains. All three domains are conserved between organisms, suggesting that these regions of Neuralized are functionally… CONTINUE READING

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