The NHR1-1 of Prs1 and the pentameric motif 284KKCPK288 of Prs3 permit multi-functionality of the PRPP synthetase in Saccharomyces cerevisiae.

@article{Sauvaget2019TheNO,
  title={The NHR1-1 of Prs1 and the pentameric motif 284KKCPK288 of Prs3 permit multi-functionality of the PRPP synthetase in Saccharomyces cerevisiae.},
  author={Ma{\"e}lle Sauvaget and Fraser Hutton and Robert Coull and Stefano Vavassori and Ke Hong Wang and Aleksandra Reznik and Tatsiana Chyker and Chelsea G Newfield and Eloise Euston and Gerrit Benary and Lilian Mary Schweizer and Michael Schweizer},
  journal={FEMS yeast research},
  year={2019},
  volume={19 2}
}
The five-membered PRS gene family of Saccharomyces cerevisiae is an example of gene duplication allowing the acquisition of novel functions. Each of the five Prs polypeptides is theoretically capable of synthesising PRPP but at least one of the following heterodimers is required for survival: Prs1/Prs3, Prs2/Prs5 and Prs4/Prs5. Prs3 contains a pentameric motif 284KKCPK288 found only in nuclear proteins. Deletion of 284KKCPK288 destabilises the Prs1/Prs3 complex resulting in a cascade of events… CONTINUE READING
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