The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells.

@article{Gu2001TheNO,
  title={The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells.},
  author={Howard Haogang Gu and Xiaosheng Wu and Bruno Giros and Marc G. Caron and Michael J Caplan and Gary Rudnick},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 12},
  pages={
          3797-807
        }
}
When expressed in epithelial cells, dopamine transporter (DAT) was detected predominantly in the apical plasma membrane, whereas norepinephrine transporter (NET) was found in the basolateral membrane, despite 67% overall amino acid sequence identity. To identify possible localization signals responsible for this difference, DAT-NET chimeras were expressed in MDCK cells and localized by immunocytochemistry and transport assays. The results suggested that localization of these transporters in… CONTINUE READING
13 Citations
77 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 77 references

Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes

  • D. F. Balkovetz, C. Tirruppathi, F. H. Leibach, V. B. Mahesh, V. Ganapathy
  • J. Biol
  • 1989
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…