The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations.

@article{Vogel2011TheNA,
  title={The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations.},
  author={Ulla Vogel and Majken Karoline Jensen and Karen Margrete Due and Eric B. Rimm and Hak̊an Wallin and Michael Ren{\'e} Skjelbo Nielsen and Anne-Pernille T Pedersen and Anne Tj\onneland and Kim Overvad},
  journal={Atherosclerosis},
  year={2011},
  volume={219 1},
  pages={200-4}
}
AIM Inflammation is a risk factor for coronary heart disease (CHD). A common deletion-allele in the promoter region of NFKB1 results in lower protein levels of the NF-κB p50 subunit. Recent evidence suggests that the NF-κB p50 dimer has anti-inflammatory effects. We aimed to investigate the association of the functional ATTG NFKB1 insertion/deletion variant with risk of CHD in three independent prospective studies of generally healthy men and women. METHODS AND RESULTS The NFKB1 ins/del… CONTINUE READING