The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner1

@article{Trama2000TheNP,
  title={The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner1},
  author={J. Trama and Qingjun Lu and R. Hawley and Steffan N. Ho},
  journal={The Journal of Immunology},
  year={2000},
  volume={165},
  pages={4884 - 4894}
}
  • J. Trama, Qingjun Lu, +1 author Steffan N. Ho
  • Published 2000
  • Biology, Medicine
  • The Journal of Immunology
NFAT DNA binding complexes regulate programs of cellular activation and differentiation by translating receptor-dependent signaling events into specific transcriptional responses. NFAT proteins, originally defined as calcium/calcineurin-dependent regulators of cytokine gene transcription in T lymphocytes, are expressed in many different cell types and represent critical signaling intermediates that mediate an increasingly wide spectrum of biologic responses. Recent studies have identified a… Expand
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  • Biology, Medicine
  • The Journal of Biological Chemistry
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It is shown that the activation state of NFAT1 in T cells is remarkably sensitive to the level of calcineurin activity, and an N-terminal region ofNFAT1 conserved in other NFAT family proteins may provide a target for the design of novel immunosuppressive drugs. Expand
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