The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.

@article{Ballester1990TheNL,
  title={The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.},
  author={R Y Ballester and Douglas A. Marchuk and Mark Boguski and Ann M. Saulino and Robert Letcher and Michael Wigler and Francis Collins},
  journal={Cell},
  year={1990},
  volume={63 4},
  pages={851-9}
}
The von Recklinghausen neurofibromatosis locus, NF1, encodes a protein with homology restricted to the catalytic region of the RAS GTPase-activating protein, GAP, and with extensive homology to the IRA1 and IRA2 gene products of the yeast S. cerevisiae. A segment of the NF1 cDNA gene, expressed in yeast, can complement loss of IRA function and can inhibit both wild-type and mutant activated human H-ras genes that are coexpressed in yeast. Yeast expressing the NF1 segment have increased H-ras… CONTINUE READING
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