The NF-kappaB pathway in human endometrium and first trimester decidua.

  title={The NF-kappaB pathway in human endometrium and first trimester decidua.},
  author={Anne E King and Hilary O D Critchley and Rodney W. Kelly},
  journal={Molecular human reproduction},
  volume={7 2},
Nuclear factor kappa B (NF-kappaB) regulates proinflammatory genes and may be involved in inflammation associated with reproductive events e.g. menstruation, implantation. Activation of NF-kappaB involves several protein kinases and subsequent degradation of an endogenous inhibitor, IkappaBalpha. This study details expression of NF-kappaB pathway intermediates in human endometrium and first trimester decidua. Messenger RNA was detected for IkappaBalpha, and IkappaB kinase gamma (IKKgamma, a… CONTINUE READING


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